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pentobarbital will reduce the extent or effect of midostaurin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Sturdy CYP3A4 inducers may perhaps lower midostaurin concentrations leading to reduced efficacy.pentobarbital boosts effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Wa